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Photothermal therapy of Fe3O4 magnetic nanoparticles and their custom synthesized composite materials

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Fe3O4 The nanoparticles used in biomedicine are characterized by their high magnetic saturation and biocompatibility. Recently, Fe3O4 Nanoparticles attracted researchers’ attention as a type of new photothermal reagent.Fe3O4 (microspheres) clusters, compared to Fe3O4 with the same crystallization, have a superior photothermal effect. This is due in part to their stronger absorption functions within the near-infrared spectrum. Fe3O4 Microspheres also showed a greater photothermal treatment under near-infrared lights.
The photothermal properties can be further explored by utilizing Fe3O4 Researchers have found that with increasing storage time, Fe3O4 is partially oxidized to Fe2O3. They also discovered that polymer ligands are more protective than small molecule ligands. Fe3O4 becomes partially oxidized with the increase in storage time. Research has shown that polymer molecules have a greater protective effect than small molecule ones, and also have a strong anti-oxidation capability.

By oxidatively polymerizing dopamine, PDA, we can prepare composite microspheres of Fe3O4&PDA with high biocompatibility. The composite microspheres exhibit greater photothermal effects and absorption near infrared compared to Fe3O4 microspheres. Both the near infrared absorption of Fe3O4&PDA Composite Microspheres and the photothermal effect increase with an increase in the thickness of PDA.
Nanoparticles will enter the blood of the body and combine quickly with different proteins to create a protein crown. This is then absorbed by the autoimmune, reticuloendothelial, and mononuclear lymphocytes. Biomimetic technology was used to create the Fe3O4 The microspheres have been coated with membranes of red blood cells (RBCs), which greatly improves their long-term circulation in the body. They also enhance the effect of photothermal therapy on the animals by enhancing the composite microspheres’ enrichment at the tumor.
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